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Selective Serotonin Reuptake Inhibitors (SSRI)

2. Class members and licensed uses

Consult the summary of product characteristics for details of authorised indications of each SSRI.

SSRIs: Approved names, common proprietary names and licensed indications

Citalopram

Escital-opram
(enantiomer 1 of citalopram)

Fluoxetine

Fluvoxamine

Paroxetine

Sertraline

Common proprietory names

Cipramil

Cipralex

Prozac

Faverin

Seroxat

Lustral

Depressive illness 2

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Generalised anxiety disorder

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Obsessive–compulsive disorder

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Panic disorder with or without agoraphobia 3

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Social anxiety disorder (social phobia)

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Post-traumatic stress disorder

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Bulimia nervosa

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1 2 3

Antidepressants in other classes may also inhibit reuptake of serotonin, but only SSRIs are discussed here.

Only the following SSRIs are licensed for children and adolescents:

  • Fluoxetine for the treatment of moderate to severe major depressive episode (in combination with psychological therapy) in children aged over eight years and adolescents
  • Fluvoxamine for the treatment of obsessive–compulsive disorder in children aged over eight years and adolescents
  • Sertraline for the treatment of obsessive–compulsive disorder in children aged over six years and adolescents.

  1. An enantiomer is one of a pair of chemical molecules with identical molecular formula, but one enantiomer cannot be superimposed on the other because it is a mirror image of the other. Often one enantiomer exerts considerably more biological activity than the other.
  2. A psychiatric disorder characterised by lowered mood, reduced energy and decreased activity. The severity of a depressive episode is divided clinically into mild, moderate and severe subtypes (the latter may or may not have psychotic features). Repeated episodes of depression, without a history of mania, are classified as recurrent depressive disorder.
  3. Abnormal fear or anxiety induced by being in crowds or in open spaces—environments which seem difficult to escape from or obtain help.