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Benzodiazepines

1.1 Class members

Benzodiazepine

Licensed indications*

Formulations

Strengths

alprazolam

Moderate to severe anxiety states; anxiety associated with depression

Tablets

250 micrograms, 500 micrograms

chlordiazepoxide

Disabling or unacceptably distressing anxiety; muscle spasm; alcohol withdrawal

Tablets

5 mg, 10 mg

clobazam

Disabling or unacceptably distressing anxiety; anxiety associated with depression (in conjunction with other treatment); adjunctive therapy of epilepsy

Tablets

10 mg

clonazepam

Epileptic disease

Tablets

500 micrograms, 2 mg

Status epilepticus

Injection

1 mg/ml: 1 ml

diazepam

Disabling or unacceptably distressing anxiety; cerebral palsy; muscle spasm; adjunctive treat­ment of epilepsy; alcohol withdrawal; premedi­cation before dental procedures or before surgery

Tablets

2 mg, 5 mg, 10 mg

Oral solution

2 mg/5 ml, 5 mg/5 ml

Sedation before medical procedures; premedication before surgery; muscle spasm (eg in tetanus or poisoning); status epilepticus; severe acute anxiety or agitation (eg delirium tremens)

Injection solution

5 mg/ml: 2 ml

Injection emulsion

5 mg/ml: 2 ml

Severe acute anxiety or agitation; convulsions; muscle spasm (eg in tetanus or poisoning); sedation before medical procedures

Rectal solution

2 mg/ml: 1.25 ml, 2.5 ml
4 mg/ml: 2.5 ml

flurazepam

Disabling or unacceptably distressing insomnia

Capsules

15 mg, 30 mg

loprazolam

Disabling or unacceptably distressing insomnia

Tablets

1 mg

lorazepam

Disabling or unacceptably distressing anxiety; premedication before dental procedures or before surgery

Tablets

1 mg, 2.5 mg

Premedication before medical procedures; acute anxiety, excitement or mania; status epilepticus

Injection

4 mg/ml: 1 ml

lormetazepam

Disabling or unacceptably distressing insomnia

Tablets

500 micrograms, 1 mg

midazolam

Acute prolonged convulsive seizures

Oromucosal solution

5 mg/ml: 0.5 ml, 1 ml, 1.5 ml, 2 ml

Sedation before medical procedures; premedication before surgery; induction of anaesthesia; sedative in combined anaesthesia; sedation for patients in intensive care

Injection

1 mg/ml: 2 ml, 5 ml, 10 ml
2 mg/ml: 5 ml, 25 ml, 50 ml
5 mg/ml: 1 ml, 2 ml, 3 ml, 5 ml, 10 ml

nitrazepam

Disabling or unacceptably distressing insomnia

Tablets

5 mg

Oral suspension

2.5 mg/5 ml

oxazepam

Disabling or unacceptably distressing anxiety

Tablets

10 mg, 15 mg

temazepam

Disabling or unacceptably distressing insomnia; premedication before medical procedures

Tablets

10 mg, 20 mg

Oral solution

10 mg/5 ml

*Consult summaries of product characteristics for up to date statements on authorised indications